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SRX21026450: GSM6605748: KU109t; Homo sapiens; RNA-Seq
1 ILLUMINA (NextSeq 500) run: 9M spots, 682.7M bases, 260.2Mb downloads

External Id: GSM6605748_r1
Submitted by: University of Texas Southwestern Medical Center
Study: Transcriptome profile of hepatocellular carcinoma from non-alcoholic fatty liver.
show Abstracthide Abstract
Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with its high prevalence and risk of developing lethal complications, progressive liver fibrosis and hepatocellular carcinoma (HCC), the only rising cancer mortality in the U.S. Ever after curative surgical resection, HCC can recur at extremely high rate (70% within 5 years); therefore, prediction of recurrent HCC is expected to guide decision of neo/adjuvant therapies currently under active development. Herein, we derived an HCC-transcriptome-based signature to predict disseminative recurrence, which originates from disseminated HCC cells from surgically resected initial tumor, and validated it in an independent cohort. Overall design: HCC tumor tissues were obtained from 45 patients who underwent surgically curative resection and used for RNA isolation and genome-wide transcriptome profiling by RNA-Seq.
Sample: KU109t
SAMN36458032 • SRS18298865 • All experiments • All runs
Organism: Homo sapiens
Library:
Name: GSM6605748
Instrument: NextSeq 500
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: SINGLE
Construction protocol: RNA was isolated from 10 micron-thick FFPE tissue using High Pure RNA Paraffin kit (Roche) according to manufacturer's protocol. Truseq RNA Exome kit (Illumina, CA) following manufacturer's protocol. Exome-enriched RNA-seq
Runs: 1 run, 9M spots, 682.7M bases, 260.2Mb
Run# of Spots# of BasesSizePublished
SRR252815278,983,515682.7M260.2Mb2023-09-14

ID:
28461043

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